How Do Your Dog’s Hormones Affect Their Health and Behavior?

dog hormones | How Do Your Dog’s Hormones Affect Their Health and Behavior? | Hormones play a vital role in a dog's health and behavior. Hormonal imbalances can lead to various health issues and behavioral changes. For example, an overactive thyroid gland can cause weight loss, restlessness, and increased appetite, while an underactive thyroid gland can result in weight gain, lethargy, and hair loss. | Wellcare World | health

Hormone levels can impact a dog’s mood, energy levels, and overall

From estrogen and testosterone to adrenaline and cortisol, your dog’s have a profound impact on their well-being — physically, mentally and emotionally.

Most people know that hormones are important for regulating body systems. These natural chemicals impact systems and metabolism on almost every level of the body, and also have a significant influence on and mood — not only in ourselves, but in our as well. Read on for a discussion of the most common hormones and how they affect your dog’s and behavior.

DEFINING HORMONES

A hormone is a chemical transmitter substance produced by cells in the body. It is transported through the bloodstream to the cells and organs on which it has a specific regulatory effect. In other words, hormones act as chemical messengers within the body, in order to stimulate or suppress certain processes or actions.

WHAT ARE SOME COMMON PLAYERS?

There are dozens and dozens of different hormones in the body, but the most well-recognized players include:

  • Testosterone
  • Estrogen
  • Adrenaline
  • Cortisol
  • Thyroid hormone
  • Growth hormone
  • Insulin
  • Melatonin

Additionally, specific neurotransmitters act as hormones in the body, and these include serotonin, dopamine, and GABA.image 2023 05 11 094139215 e1683823312535 | How Do Your Dog’s Hormones Affect Their Health and Behavior? | Hormones play a vital role in a dog's health and behavior. Hormonal imbalances can lead to various health issues and behavioral changes. For example, an overactive thyroid gland can cause weight loss, restlessness, and increased appetite, while an underactive thyroid gland can result in weight gain, lethargy, and hair loss. | Wellcare World | health

All these hormones act within complex networks collectively referred to as the endocrine system. The endocrine system is a network of glandular organs that produce and regulate hormones to control and coordinate the body’s metabolism, energy level, reproduction, growth and development, response to injury and/or stress, and mood.

Crucially important glands within the endocrine system include:

  • Hypothalamus
  • Pineal gland
  • Pituitary gland
  • Thyroid gland
  • Parathyroid gland
  • Thymus
  • Adrenal gland
  • Pancreas
  • Ovaries
  • Testes

The gut ( tract) also acts as an endocrine gland since it works with endocrine cells, neurons, and immune cells, using gut peptides as signaling substances. In fact, some of the hormones in the gut are also found in the brain, which supports the concept of the gut-brain axis.

AND ENDOCRINE DISEASES

These health problems are very common in our canine companions, and appear to be on the rise. There are many reasons for this, such as:

  1. Processed foods and toxins: Many toxins are known to be direct endocrine disruptors, and include common food preservatives such BPA and BHA, and herbicides in foods such as glyphosate (Roundup).
  2. Nutrient deficiencies: Trace minerals such as magnesium, selenium, zinc, potassium and iodine are critically important for the body’s glands to function appropriately. Trace mineral deficiencies are very common in both dogs and humans.
  3. Spaying and neutering: Typically, when pets are de-sexed, the gonads (ovaries or testicles) are completely removed, which means the majority of testosterone and estrogen are gone for good. It is important to note that a certain level of sex hormones is crucially important for sustaining normal health and well-being.

image 2023 05 11 094231926 e1683823368165 | How Do Your Dog’s Hormones Affect Their Health and Behavior? | Hormones play a vital role in a dog's health and behavior. Hormonal imbalances can lead to various health issues and behavioral changes. For example, an overactive thyroid gland can cause weight loss, restlessness, and increased appetite, while an underactive thyroid gland can result in weight gain, lethargy, and hair loss. | Wellcare World | healthAs it turns out, the only other glands in the body that can produce some sex hormones are the adrenal glands. This means the adrenal glands in a spayed or neutered dog are placed under extra stress and demand throughout the animal’s lifetime. The adrenal glands are also responsible for regulating and releasing adrenaline and cortisol hormones, which is in itself a big job. Adrenaline is the hormone released during the body’s fight or flight response, triggered when stressful events occur.

Cortisol is also released by the adrenals in fight or flight scenarios, and is continually released in chronic stress situations. Ongoing stressors for dogs can include things like chronic , chronic itching due to allergies, environmental stressors, household upsets, separation anxiety, etc.

CHRONIC ANXIETY AND THE HPA AXIS

Chronic anxiety is becoming more common in animals, with growing numbers of dogs being placed on prescription medications to manage it. The common metabolic causes of anxiety include HPA dysfunction, compromised gut health, and nutrient deficiencies.

  • The HPA axis describes the hypothalamic-pituitary-adrenal system, which is known as the command center and communication feedback system in the part of the brain that senses stress. The HPA axis controls reactions to stress and regulates digestion and the immune system, as well as mood and emotions.
  • When this system is continually firing under conditions of chronic stress, the negative feedback loop mechanism (which normally keeps things in check) can break down. This HPA dysfunction is recognized as a cause of chronic anxiety.
  • If the situation continues, this dysfunction can lead to adrenal gland depletion, otherwise known as adrenal fatigue. Other health conditions associated with adrenal dysfunction include Cushing’s and Addison’s diseases. All these adrenal gland conditions can affect a dog’s behavior, causing everything from anxiety and restlessness to low energy and fatigue.

ESTROGEN AND TESTOSTERONE

If your dog is still sexually intact, they will have higher levels of sex hormones — i.e. testosterone in males and estrogen and progesterone in females. These can certainly also affect behavior and mood.

  • Testosterone is known to influence confidence, dominance, and potentially aggression. However, this is not to say a neutered dog won’t display these behaviors. In fact, some dog parents see their dogs’ aggressive or reactive behaviors actually heighten after neutering; it appears that, in some circumstances, removing the confidence-supporting testosterone hormone could lead to more fear-related aggression behaviors. This demonstrates that hormones have very complex effects on the body, mind and mood.
  • Estrogen is known to help regulate mood. In human women, low levels of estrogen are shown to influence anxiety, depression and stress.
  • Progesterone is a “feel good” hormone that has a calming effect. In female dogs, progesterone is released after ovulation during the heat cycle, whether they are bred or not (even if they do not become pregnant), and continues to be measured at high levels for many weeks after.

In conclusion, it’s clear that hormones exert vast effects on the body and directly influence the emotional and mental well-being of our dogs and ourselves.

The post How Do Your Dog’s Hormones Affect Their Health and Behavior? appeared first on Animal Wellness Magazine.

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Why DIY Rat Cages Are Not the Best Idea for Rats

Thinking about creating a DIY rat cage? It might seem like a fun and budget-friendly idea, but there are some important factors to consider before diving into the DIY world.

Let’s explore why DIY rat cages might not be the ideal option for your furry friends. We’ll cover topics like ventilation, materials, and potential costs!

Risks

need plenty of fresh air in their cage to stay healthy. They produce urine that contains ammonia, which can be harmful if it accumulates in their living space. Inadequate ventilation can lead to respiratory stress, which can lead to serious health issues. So, ensuring proper airflow is a must for rat housing.

Designing a DIY cage that balances durability and airflow can be quite tricky.

Plus, rats are notorious chewers! They’ll happily nibble on anything within reach, including cage stands and walls. This chewing habit can weaken the structure of your DIY cage, posing risks to your rats.

Unsuitable Materials

Wood is often the go-to material for DIY rat cages due to its versatility and ease of customization. However, it’s not a suitable choice for housing rats.

These little critters love to chew, and wood is no exception. They can quickly chew through wooden structures, turning your DIY masterpiece into an escape route for your rats.

On top of that, wood is almost impossible to clean thoroughly, which is crucial for maintaining a healthy and hygienic environment for the rats. While you can easily remove and clean wooden cage accessories individually, cleaning a wooden-based DIY enclosure as a whole can be a real hassle.

Another option is plastic which poses no health hazard, but rats can easily chew through it.

I’ve also seen cages made of glass. These are absolutely unsafe as they trap ammonia in the cage and don’t allow it to disperse.

Space

When it comes to rat cages, size matters! It’s important to give your furry friends plenty of room to roam and play. Ideally, a rat cage should measure at least 32×20 inches or 80×50 centimeters in floor space. However, creating such a spacious DIY cage can be quite a challenge. In fact, many DIY cages I’ve come across often fall short in terms of floor space.

We all want the best for our little companions, and that includes providing them with ample space to move around and explore. Unfortunately, DIY cages may not always meet these size requirements, as they can be tricky to design and construct on a larger scale.

Rat cage Critter Nation one story 850 | Why DIY Rat Cages Are Not the Best Idea for Rats | DIY rat cages may seem like a cost-effective option, but they may not meet the specific needs of rats. Commercial rat cages are designed with safety features, proper ventilation, easy maintenance, and ample space for enrichment. | Wellcare World | health

A rat cage should have a volume of over 8 cubic feet.

Consider the Costs

Compared to ready-made rat cages available in stores, DIY enclosures come with their fair share of risks and potential expenses.

Designing and building a DIY cage that meets your rats’ needs can be time-consuming and end up being more costly. It requires careful planning, knowledge of suitable materials, and some DIY skills. Without these resources, creating a safe and suitable DIY cage can be quite a challenge.

If you’re considering DIY because you’re on a budget, your best bet is to check platforms like Facebook Marketplace, Craigslist, and local exotic animal groups. You can often find high-quality enclosures at affordable prices when buying second-hand. This way, you’ll not only save money but also eliminate the risks and uncertainties associated with DIY rat cages.

Prioritizing Rat Happiness

Choosing the right cage is crucial for the of your rats. Their overall health depends on proper care and suitable living conditions. Investing in a well-designed and purpose-built rat cage ensures your rats have enough space and proper ventilation.

By focusing on their needs, you’ll be providing them with a comfortable and enjoyable environment.

Factors to Consider When Making a DIY Rat Cage

If you are considering the option of building your own rat cage, there are several important factors to keep in mind to ensure the well-being of your pets.

Follow these guidelines for a comfortable and suitable rat habitat:

  • Size: It is essential to provide your rats with ample room to move and explore. A cage with a floor space of at least 32×20 inches (80×50 cm) will allow them to roam and engage in their natural behaviors.
  • Adequate Ventilation: Ideally, all four sides and the top of the cage should be fully ventilated to ensure your rats get enough fresh air.
  • Suitable Materials: Wood is a bad choice as it absorbs the pee, and both plastic and wood can be chewed through and pose an escape risk. A fully metal cage would be the best choice, as it can’t be chewed and it’s not absorbent.
  • Bar Spacing: The bar spacing needs to be small enough to prevent any Houdini-like escapes. A gap between bars measuring ½ inch (1 – 1.5 cm) will keep your rats securely inside the cage.
  • Substrate Requirements: Rats are burrowing animals and benefit greatly from having substrate to dig in. When constructing your DIY cage, make a cage base at least 6 inches (15 cm) tall. This way, you can add a minimum of 4 inches (10 cm) of the substrate while having a few inches as a scatter guard. If that’s not an option, add digging boxes in the finished cage setup.

Examples of Bad & Unsuitable DIY Rat Cages

Browsing around the internet, I wasn’t able to find many suitable DIY rat cages with proper ventilation, made of safe materials, and enough floor space. In contrast, there’s a fair share of bad DIY rat cages that don’t provide adequate housing. Here are some examples so you know what not to do.

Bad DIY rat cages (what not to do):

Example of a bad DIY rat cage
Cages made of glass are not safe.
Image from Wikimedia (CC BY-SA 3.0)

Conclusion

While DIY projects can be a blast, DIY rat cages might not be the best option for your furry friends. The challenges of ventilation, the pitfalls of wooden structures, and the potential risks and costs involved make ready-made rat cages a more reliable choice.

So, instead of embarking on a potentially complicated and expensive DIY project, consider checking out affordable, high-quality second-hand cages on platforms like Facebook Marketplace or Craigslist.

By putting your rats’ well-being first and selecting the right cage, you’ll ensure they have a cozy and safe home they’ll love to call their own.

The post Why DIY Rat Cages Are Not the Best Idea for Rats appeared first on Animallama.

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Even Moderate Drinking Is Not Good for Your Health

Even Moderate Drinking Is Not Good for Your Health

Decades of conflicting reports seem to have finally resolved into a clear, buzz-killing picture, while yet another study confirms it:

No amount of consumption will protect against disease or extend
your lifespan, according to a sweeping review published in late March.

The meta-analysis, printed in the Journal of the American Medical Association, draws on more than a hundred studies involving nearly 5 million people.

The researchers found that just 25 grams a day for women and 45 for men — roughly two and three drinks, respectively — carries a significant risk.

Tim Stockwell, lead author and professor of psychology at the University of Victoria, recognizes this isn’t welcome news for many casual drinkers.

“It’s our favorite recreational drug,” he says, adding some sobering advice. “Don’t kid yourself that it’s going to improve your health. The evidence for that is shakier and shakier as the research piles up.”

The French Paradox

The belief that alcohol in moderation is good for you originated in the 1980s with the so-called French paradox — despite their seemingly high-fat diet, men in France were unexpectedly free from cardiovascular disease.

Early research attributed the phenomenon to their fondness for , and although further investigation disproved it, the idea persisted.

Many subsequent studies pointed to a link between moderate alcohol consumption and general , but as the adage goes, correlation does not imply causation.

Stockwell and his colleagues concluded that most previous estimates were riddled with biases, skewing the results to give alcohol more credit than it deserves.

Reinterpreting the Health Effects of Alcohol

In those studies, the relationship between alcohol and all-cause mortality — death by everything from disease to injury — has typically appeared as a J-shaped distribution curve.

The tail represents abstainers, at relatively high-risk; the dip represents moderate drinkers, at lowest risk; and from there the slope rises steadily, as risk increases with every glass. But this version of the story is misleading, Stockwell says.

For one, the comparison with abstainers is unfair.

That category often includes former drinkers who gave it up due to illness. Others who forgo alcohol may not be able to afford it, and lower socioeconomic status comes with a host of health challenges.

On the flip side, anyone who limits themselves to a drink or two regularly probably has a long list of advantages. They are likely to be wealthier, better educated and more physically active, for example.

In other words, “It’s not the moderate that’s healthy, it’s the moderate drinker,” says Aaron White, senior scientific advisor to the director at the National Institute on Alcohol Abuse and Alcoholism, who was not involved in the study.

Cheers with drinks

(Credit: Mooi Design/Shutterstock)

Fixing the Flaws

When the authors of the new analysis adjusted for these factors, removing the bias as well as possible, the dip in the J (that is, the risk of death for moderate drinkers) sprang up much closer to the height of the tail.

Alcohol’s protective effect all but disappeared.

They weren’t able to fully correct the flaws of previous studies, however, so even the updated results must be taken with a grain of salt.

“My gut feeling,” Stockwell says, “is that when we do better research, we’ll find that we’ve been underestimating alcohol’s risk at every level.”

Effects Alcohol Has on the Body

The moment you ingest any amount of ethanol, he believes, you boost your chance of cancer, liver disease and myriad other health problems.

That’s not to say the occasional drink is a death sentence — small servings, small danger might be a good rule of thumb.

In White’s view, it just means you should consider alcohol like cake, or anything else that’s pleasurable but has potentially harmful side effects.

“If you enjoy it and you’re willing to take the risk,” he says, there’s no need to swear it off entirely.

More Convincing Research

The JAMA study isn’t the first to cast doubt on alcohol’s role in health.

Last year a team of MIT and Harvard researchers analyzed genetic and medical data for nearly 400,000 people, and found that even small amounts of alcohol were linked to heart disease, though the risk increased exponentially at higher levels.

One problem with most research to date, in addition to methodological biases, is that it was based on observational studies, which can’t prove cause and effect.

Genetic evidence adds much-needed diversity to the field’s literature, Stockwell says.

Designing the Perfect Trial

The gold standard would be a randomized controlled trial, in which participants volunteer to maintain consistent drinking habits — some would abstain, others would have a drink a day, others two or three.

By tracking them over the course of their lives, researchers would glean far more accurate information. Such a project would be almost prohibitively expensive.

The National Institutes of Health began a similar effort in 2013, then shut it down in 2018 amid concerns that NIH officials had compromised their impartiality as they sought $100 million in funding from the world’s largest brewer, Anheuser-Busch InBev and Heineken.

Historically, many studies demonstrating the health benefits of moderate drinking have been funded by the alcohol industry, leading some experts to question their results based not only on methodology, but also on conflict of interest.

A Sobering Consensus

Despite the difficulties of conducting ideal research at the proper scale, scientific consensus seems to have settled decisively.

Even red wine — which contains the antioxidant resveratrol and was long thought to prevent coronary artery disease — has lost defenders.

In a policy brief published last year, the World Heart Federation declared unambiguously that “contrary to popular opinion, alcohol is not good for the heart.”

Dietary authorities have also grown more cautious in their messaging over the past decade.

The latest U.S. guidelines recommend no more than two drinks per day for men and one for women, adding that “even drinking within the recommended limits may increase the overall risk of death.”

Notably, though, the guidelines don’t advocate sobriety, per se. They state that no one should drink specifically to improve their health.

Alcohol Industry Response

Even industry representatives, who have historically portrayed moderate drinking as part of a well-balanced life, now echo this point.

Amanda Berger, vice president for and health with the Distilled Spirits Council, criticized certain aspects of the new research but conceded that “no one should drink alcohol to obtain potential health benefits,” according to the New York Times.

There’s still something to be said for alcohol, in White’s opinion, when you factor in the enjoyment it brings some people.

But as for its direct effect on our health, “the conversation is really changing,” he says. “Alcohol is not good medicine, and I think that is ultimately what we’re seeing here.”

By Cody Cottier

 

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CMS announces plan for NEW Alzheimer’s medications

CMS announces plan for NEW Alzheimer’s medications

Centers for Medicare & Medicaid Services (CMS) Administrator Chiquita Brooks-LaSure announced today how people can get drugs that may slow the progression of Alzheimer’s disease covered by Medicare. If the Food and Drug Administration (FDA) grants traditional approval, then Medicare will cover it in appropriate settings that also support the collection of real-world information to study the usefulness of these drugs for people with Medicare.

“Alzheimer’s disease takes a toll on not just the people suffering from the disease but also on their loved ones and caregivers in a way that almost no other illness does. CMS has always been committed to helping people obtain timely access to innovative treatments that meaningfully improve and outcomes for this disease,” Brooks-LaSure said. “If the FDA grants traditional approval CMS is prepared to ensure anyone with Medicare Part B who meets the criteria is covered. I’m pleased to make this announcement today as part of CMS’ mission to help improve the lives of Americans we serve. I hope we see more private sector partners in this work making their own announcements soon.”

FDA Timeline

The FDA’s Peripheral and Central Nervous System Drugs Advisory Committee will discuss the results of a confirmatory trial of the Eisai product Leqembi on June 9, with a potential decision on traditional approval possible within weeks. Broader Medicare coverage would begin on the same day the FDA grants traditional approval. Under CMS’ current coverage policy, if FDA grants traditional approval to other drugs in this class they would also be eligible for broader coverage. Currently two drugs in this class have received accelerated approval from the FDA, but no product has received traditional approval.

Medicare Drug Inclusions

Medicare will cover drugs with traditional FDA approval when a physician and clinical team participates in the collection of evidence about how these drugs work in the real world, also known as a registry. Clinicians will be able to submit this evidence through a nationwide, CMS-facilitated portal that will be available when any product gains traditional approval and will collect information via an easy-to-use format. This method, and any others that may follow, will adhere to robust privacy protections in accordance with applicable federal laws and regulations, including HIPAA. Researchers will have access to the information to conduct studies, furthering knowledge of how these drugs can potentially help people. CMS is working with multiple organizations that are getting ready to open their own registries. More information will be released as they come on line.

Roll Out How’s

The approach is consistent with CMS’ National Coverage Determination. To get Medicare coverage people will need to 1) be enrolled in Medicare Part B, 2) be diagnosed with mild cognitive impairment or early dementia caused by Alzheimer’s disease, and 3) have a qualified physician participating in a registry, including the options above, with an appropriate clinical team and follow up care. These criteria are in addition to any label requirements the FDA specifies.

Registries are common tools in clinical settings that have successfully gathered information on patient outcomes for decades. There is strong precedent for using registries to gather more information on a newly-approved treatment. For example, when the FDA granted traditional approval to the transcatheter aortic valve replacement (TAVR), CMS required the clinicians and hospitals to participate in a registry to track outcomes. Information gathered from that registry has since been used to further inform Medicare coverage determinations, and to help people and their clinicians make better decisions about whether TAVR is the best treatment for them.

Additional Information from CMS

Other registries for drugs that may slow the progression of Alzheimer’s disease may become available in the coming weeks and months. Information will be available at https://www.cms.gov/Medicare/Coverage/Coverage-with-Evidence-Development as studies come on line.

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